Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Ergonomic insole ODM support China
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.ODM pillow for sleep brands Vietnam
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene sheet OEM supplier factory Taiwan
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Researchers have identified the genetic pathway between the heart and brain responsible for fainting, revealing a two-way communication that could lead to new treatments for syncope-related disorders. Neurobiologists have discovered sensory neurons that regulate fainting, providing a foundation for targeted treatments for related disorders. Syncope, commonly known as fainting, affects nearly 40 percent of people at least once in their lifetime. These transient losses of consciousness can be precipitated by various triggers such as pain, fear, heat, or hyperventilation, and they are a substantial cause of emergency room visits. Despite their prevalence, the fundamental mechanisms underlying syncope have largely remained enigmatic. Breakthrough in Genetic Pathways Publishing a new report in Nature, University of California San Diego researchers, along with colleagues at The Scripps Research Institute and other institutions, have for the first time identified the genetic pathway between the heart and brain tied to fainting. One of their unique approaches was to think of the heart as a sensory organ rather than the longstanding viewpoint that the brain sends out signals and the heart simply follows directions. School of Biological Sciences Assistant Professor Vineet Augustine, the paper’s senior author, applies a variety of approaches to better understand these neural connections between the heart and brain. An image of a heart labeled by vagal sensory neurons. In a new study published in the journal Nature, UC San Diego researchers and their colleagues found that these neurons trigger fainting, laying a foundation for addressing fainting-related disorders. Credit: Augustine Lab, UC San Diego “What we are finding is that the heart also sends signals back to the brain, which can change brain function,” said Augustine. Information resulting from the study could be relevant to better understanding and treating various psychiatric and neurological disorders linked with brain-heart connections, the researchers note in their paper. “Our study is the first comprehensive demonstration of a genetically defined cardiac reflex, which faithfully recapitulates characteristics of human syncope at physiological, behavioral, and neural network levels.” Study on the Bezold-Jarisch Reflex Augustine, along with Biological Sciences Staff Research Associate Jonathan Lovelace and Graduate Student Jingrui Ma, the first authors of the paper, and their colleagues studied neural mechanisms related to Bezold-Jarisch reflex (BJR), a cardiac reflex first described in 1867. For decades researchers have hypothesized that the BJR, which features reduced heart rate, blood pressure, and breathing, may be associated with fainting. But information lacked in proving the idea since the neural pathways involved in the reflex were not well known. Researchers at UC San Diego and collaborating institutions have highlighted the immense crosstalk between the heart and the nervous system. The video displays heart activity dramatically slowing down with stimulation of vagal sensory neurons, which were found to trigger fainting. Credit: Augustine Lab, UC San Diego The researchers focused on the genetics behind a sensory cluster known as the nodose ganglia, which are part of the vagus nerves that carry signals between the brain and visceral organs, including the heart. Specifically, vagal sensory neurons, or VSNs, project signals to the brainstem and are thought to be associated with BJR and fainting. In their search for a novel neural pathway they discovered that VSNs expressing the neuropeptide Y receptor Y2 (known as NPY2R) are tightly linked to the well-known BJR responses. Optogenetic Studies and Findings Studying this pathway in mice, the researchers were surprised to find that when they proactively triggered NPY2R VSNs using optogenetics, a method of stimulating and controlling neurons, mice that had been freely moving about immediately fainted. During these episodes, they recorded from thousands of neurons in the brains of the mice, as well as heart activity and changes in facial features including pupil diameter and whisking. They also employed machine learning in several ways to analyze the data and pinpoint features of interest. Once NPY2R neurons were activated, they found, mice exhibited rapid pupil dilation and the classic “eye-roll” seen during human fainting, as well as suppressed heart rate, blood pressure, and breathing rate. They also measured reduced blood flow to the brain, an area of collaboration with Professor David Kleinfeld’s laboratory in the UC San Diego Departments of Neurobiology and Physics. “We were blown away when we saw how their eyes rolled back around the same time as brain activity rapidly dropped,” the researchers reported in a paper summary. “Then, after a few seconds, brain activity and movement returned. This was our eureka moment.” Further testing showed that when NPY2R VSNs were removed from mice, the BJR and fainting conditions vanished. Previous studies have shown that fainting is caused by a reduction in brain blood flow, which the new study also found to be true, but the new evidence indicated that brain activity itself could be playing an important role. The findings, therefore, implicate the activation of the newly genetically identified VSNs and their neural pathways not only with BJR, but more centrally in overall animal physiology, certain brain networks, and even behavior. Implications and Future Research Such findings were difficult to tease out previously because neuroscientists study the brain and cardiologists study the heart, but many do so in isolation of the other. “Neuroscientists traditionally think the body just follows the brain, but now it is becoming very clear that the body sends signals to the brain and then the brain changes function,” said Augustine. As a result of their findings, the researchers would like to continue tracking the precise conditions under which vagal sensory neurons are triggered into action. “We also hope to more closely examine cerebral blood flow and neural pathways in the brain during the moment of syncope, to better understand this common but mysterious condition,” they note. They also hope to use their research as a model to develop targeted treatments for fainting-associated conditions. The study was funded by UC San Diego, Scripps Research Institute, the Helen Dorris Foundation, the National Institutes of Health, the American Heart Association Early Faculty Independence Award, the Mallinckrodt Foundation, the Dorris Scholarship, the Dorris-Skaggs Fellowship, and the Shurl and Kay Curci Foundation Fellowship.
Imaging of human intestinal tissue in inflammatory bowel disease showing the presence of metaplastic epithelial glands. Credit: A. Oliver, N. Huang, R. Li, et al. (2024) A new gut cell atlas, comprising data from 1.6 million cells, offers unprecedented insights into gastrointestinal health and disease. A research team led by the Wellcome Sanger Institute has created the most comprehensive cell map of the human gut to date by combining spatial and single-cell data from 1.6 million cells. This atlas provides unprecedented insights into conditions such as bowel cancer and Inflammatory Bowel Disease (IBD). Using this resource, the team uncovered a new role of a specific gut cell, highlighting its contributions to a cycle of inflammation that may cause pain and distress in some individuals. A new study published in Nature details how the team harmonized over 25 single-cell datasets of the human gastrointestinal (GI) tract to create the world’s largest freely available resource on the human gut to date. This includes samples from both those with and without health conditions. Imaging of human intestinal tissue in inflammatory bowel disease showing the presence of metaplastic epithelial glands. Credit: A. Oliver, N. Huang, R. Li, et al. (2024) Impact on Health and Disease Research By gaining a more comprehensive understanding of the human gut in both health and disease, researchers can identify key changes or differences linked to conditions such as ulcerative colitis and Crohn’s disease. This insight may lead to new potential targets for drug development. This paper is part of a collection of over 40 HCA publications in Nature Portfolio journals that represent a milestone leap in our understanding of the human body. These complementary studies have shed light on central aspects of human development and health and disease biology and led to the development of vital analytical tools and technologies, all of which will contribute to the creation of the Human Cell Atlas.[1] Imaging of human intestinal tissue in inflammatory bowel disease showing the presence of metaplastic epithelial glands. Credit: A. Oliver, N. Huang, R. Li, et al. (2024) Global Incidence and Impact of GI Conditions The GI tract is the general name for a group of organs involved in the digestive system that work together to absorb nutrients from our food and act as a barrier against pathogens. It starts at the mouth and includes the throat, esophagus, stomach, small intestine, large intestine, rectum, and anus. GI tract conditions impact millions of lives around the world. For example, ulcerative colitis and Crohn’s disease, which are both types of IBD, affect over seven million people worldwide,[2] with one in every 123 people in the UK living with IBD.[3] IBD symptoms can vary between people and have a huge impact on a person’s life. These include abdominal pain, diarrhea, rectal bleeding, extreme fatigue, and joint problems.[4] Bowel cancer, also known as colorectal cancer, starts in the large intestine and is the fourth most common cancer in the UK, with almost 43,000 people diagnosed every year.[5] Globally, there are around two million cases,[6] and it is estimated that one in 17 men and one in 20 women will be diagnosed with bowel cancer during their lifetime.[5] Imaging of human intestinal tissue in inflammatory bowel disease showing the presence of metaplastic epithelial glands. Credit: A. Oliver, N. Huang, R. Li, et al. (2024) Advances in Cellular Research Tools Due to the impact of these conditions, there have been multiple single-cell studies investigating the cellular structure of the GI tract in health and disease. These studies have separate processes and labeling systems, which can create difficulties when external researchers attempt to use them. In this latest study, researchers from the Wellcome Sanger Institute and collaborators developed a new tool to harmonize these data, creating a standardized resource of gut cells that is available to researchers worldwide. This tool could also be applied to other organs and help facilitate further studies. The team merged 25 datasets, resulting in an atlas of 1.6 million cells containing both single-cell and spatial data, allowing researchers to see what cells were present, where they were located, and how they communicated with the environment around them. The atlas was created with data from tissue samples from those without GI issues, as well as those with gastric and colorectal cancers, celiac disease, ulcerative colitis, and Crohn’s disease. Imaging of human intestinal tissue in inflammatory bowel disease showing the presence of metaplastic epithelial glands. Credit: A. Oliver, N. Huang, R. Li, et al. (2024) Role of Gut Metaplastic Cells in Inflammation The team also identified a type of gut cell that may have a role in inflammation. The cells, known as gut metaplastic cells, are known to be involved in healing the stomach lining. However, the team discovered that these cells contained genetic similarities to other GI cells involved in inflammation. They suggest that inflammation in IBD leads to changes in these metaplastic cells, which actively contributes to further inflammatory responses. By understanding more about this cycle of inflammation, it might be possible to find new ways to prevent or treat this in IBD and possibly apply this knowledge to other tissues and conditions. Conclusion and Future Prospects The Gut Cell Atlas is freely available, and the team has developed new processes to allow future studies to be added, creating an evolving, accessible resource for scientists. Dr. Amanda Oliver, first author from the Wellcome Sanger Institute, said: “Spatial and single-cell data provide unique information about how gut cells interact, that can be used to continue piecing together an in-depth understanding of how the human body works. Combining existing single-cell datasets allows us to create a more complete picture of the human gut and ensures that researchers can work together to continue to benefit human health. Our Gut Cell Atlas is also harmonized and freely available, and we hope that people will continue to build on this, adding in data for scientists worldwide to use.” Dr. Rasa Elmentaite, co-senior author previously at the Wellcome Sanger Institute and currently at Ensocell Therapeutics, said: “As the integrated atlas contains such a large amount of data, from people with and without gut conditions, we were able to uncover a pathogenic cell type that may play a role in some chronic conditions and could be a target for intervention in the future. This demonstrates the power of using integrated single-cell atlases in research, and I am confident that applying this approach to other tissues and organs will drive new therapeutic discoveries for a range of conditions.” Professor Sarah Teichmann, co-senior author and co-founder of the Human Cell Atlas, previously at the Wellcome Sanger Institute and now at the Cambridge Stem Cell Institute at the University of Cambridge, said: “A detailed understanding of cells through the Human Cell Atlas will help explain many aspects of human health and disease and possibly illuminate new avenues for treatment. This harmonized Gut Cell Atlas shows what can be achieved through open collaboration with scientists worldwide, and has led to an accessible combined resource that can be used by everyone to find new ways to understand and treat disease.” Notes The HCA is an international collaborative consortium whose mission is to create comprehensive reference maps of all human cells—the fundamental units of life—as a basis for understanding human health and for diagnosing, monitoring, and treating disease. The HCA community is producing high-quality Atlases of tissues, organs, and systems, to create a milestone Atlas of the human body. More than 3,500 HCA members from over 100 countries are working together to achieve a diverse and accessible Atlas to benefit humanity across the world. Discoveries are already informing medical applications from diagnoses to drug discovery, and the Human Cell Atlas will impact every aspect of biology and healthcare, ultimately leading to a new era of precision medicine. https://www.humancellatlas.org “Global burden of inflammatory bowel disease” by Vipul Jairath and Brian G Feagan, 21 October 2019, The Lancet Gastroenterology & Hepatology. DOI: 10.1016/S2468-1253(19)30358-9 New research shows over 1 in 123 people in UK living with Crohn’s or Colitis. (2022) Crohn’s & Colitis UK, available at: https://crohnsandcolitis.org.uk/news-stories/news-items/new-research-shows-over-1-in-123-people-in-uk-living-with-crohn-s-or-colitis [Accessed July 2024] Symptoms, Crohn’s & Colitis UK, available at: https://crohnsandcolitis.org.uk/info-support/information-about-crohns-and-colitis/all-information-about-crohns-and-colitis/symptoms?parent=23151&page=1&tags=&category=23151&sort=newest Bowel cancer. (reviewed June 2024) Bowel Cancer UK, available at: https://www.bowelcanceruk.org.uk/about-bowel-cancer/bowel-cancer/ [Accessed November 2024] Reference: “Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN” by Eileen Morgan, Melina Arnold, A Gini, V Lorenzoni, C J Cabasag, Mathieu Laversanne, Jerome Vignat, Jacques Ferlay, Neil Murphy and Freddie Bray, 1 February 2023, Gut. DOI: 10.1136/gutjnl-2022-327736 Reference: “Single-cell integration reveals metaplasia in inflammatory gut diseases” by Amanda J. Oliver, Ni Huang, Raquel Bartolome-Casado, Ruoyan Li, Simon Koplev, Hogne R. Nilsen, Madelyn Moy, Batuhan Cakir, Krzysztof Polanski, Victoria Gudiño, Elisa Melón-Ardanaz, Dinithi Sumanaweera, Daniel Dimitrov, Lisa Marie Milchsack, Michael E. B. FitzPatrick, Nicholas M. Provine, Jacqueline M. Boccacino, Emma Dann, Alexander V. Predeus, Ken To, Martin Prete, Jonathan A. Chapman, Andrea C. Masi, Emily Stephenson, Justin Engelbert, Sebastian Lobentanzer, Shani Perera, Laura Richardson, Rakeshlal Kapuge, Anna Wilbrey-Clark, Claudia I. Semprich, Sophie Ellams, Catherine Tudor, Philomeena Joseph, Alba Garrido-Trigo, Ana M. Corraliza, Thomas R. W. Oliver, C. Elizabeth Hook, Kylie R. James, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Matthias Zilbauer, Julio Saez-Rodriguez, Marte Lie Høivik, Espen S. Bækkevold, Christopher J. Stewart, Janet E. Berrington, Kerstin B. Meyer, Paul Klenerman, Azucena Salas, Muzlifah Haniffa, Frode L. Jahnsen, Rasa Elmentaite and Sarah A. Teichmann, 20 November 2024, Nature. DOI: 10.1038/s41586-024-07571-1 This research was part-funded by Wellcome; a full acknowledgment list can be found in the publication.
A team led by the University of Tsukuba has found key differences that explain why some species of fungi can grow successfully through tiny gaps, whereas other fungi–typically those with faster growth rates–cannot squeeze through and stop growing. The trade-off between developmental plasticity and growth rate helps to understand how fungi penetrate surfaces or plant/animal tissues, with important implications for fungal biotechnology, ecology, and studies of disease. Credit: University of Tsukuba University of Tsukuba research team sheds new light on how fungi that cause diseases can penetrate tissues by squeezing through tiny gaps between plant or animal cells. Fungi are a vital part of nature’s recycling system of decay and decomposition. Filamentous fungi spread over and penetrate surfaces by extending fine threads known as hyphae. Fungi that cause disease within living organisms can penetrate the spaces between tightly connected plant or animal cells, but how their hyphae do this, and why the hyphae of other fungal species do not, has been unclear. Now, a team led by Professor Norio Takeshita at University of Tsukuba, with collaborators at Nagoya University and in Mexico, has discovered a key feature that helps explain the differences among species. They compared seven fungi from different taxonomic groups, including some that cause disease in plants. The team tested how the fungi responded when presented with an obstruction that meant they had to pass through very narrow channels. At only 1 micron wide, the channels were narrower than the diameter of fungal hyphae, typically 2-5 microns in different species. Some species grew readily through the narrow channels, maintaining similar growth rates before meeting the channel, while extending through it, and after emerging. In contrast, other species were seriously impeded. The hyphae either stopped growing or grew very slowly through the channel. After emerging, the hyphae sometimes developed a swollen tip and became depolarized so that they did not maintain their previous direction of growth. The tendency to show disrupted growth did not depend on the diameter of the hyphae, or how closely related the fungi were. However, species with faster growth rates and higher pressure within the cell were more prone to disruption. By observing fluorescent dyes in the living fungi, the team found that processes inside the cell became defective in the fungi with disrupted growth. Small packages (vesicles) that supply lipids and proteins (needed for assembling new membranes and cell walls as hypha extend) were no longer properly organized during growth through the channel. “For the first time, we have shown that there appears to be a trade-off between cell plasticity and growth rate,” says Professor Takeshita. “When a fast-growing hypha passes through a narrow channel, a massive number of vesicles congregate at the point of constriction, rather than passing along to the growing tip. This results in depolarized growth: the tip swells when it exits the channel, and no longer extends. In contrast, a slower growth rate allows hyphae to maintain correct positioning of the cell polarity machinery, permitting growth to continue through the confined space.” As well as helping explain why certain fungi can penetrate surfaces or living tissues, this discovery will also be important for future research into fungal biotechnology and ecology. Reference: Trade-off between Plasticity and Velocity in Mycelial Growth” by Sayumi Fukuda, Riho Yamamoto, Naoki Yanagisawa, Naoki Takaya, Yoshikatsu Sato, Meritxell Riquelme and Norio Takeshita, 16 March 2021, mBio. DOI: 10.1128/mBio.03196-20
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